Taking 2 Adderall XR at the Same Time

Taking 2 Adderall XR at the same time is not an issue at all. You may take if you have already informed your doctor about it and if it is within your daily dose as recommended by your doctor.
Your daily dose depends among other things on your body weight. You should take this decision only if your doctor is on-board with it.

Adderall XR

What do you Know About Adderall XR?

Adderall XR is basically a central nervous system stimulant used to treat ADHD. It is a Schedule II drug that works by converting certain natural chemicals in the brain. It can increase concentration, help people stay on the work longer, and manage behavioral issues associated with ADHD.

Adderall XR is a extended-released version of Adderall. Half the dose works fast, and the other half starts working in four hours. Amphetamine salt combo XR (amphetamine and dextroamphetamine salts) is a standard version.

Description of Adderall XR

Adderall XR is a once daily extended-release, single-entity amphetamine product. Adderall XR combines the neutral sulfate salts of dextroamphetamine and amphetamine, with the dextro isomer of amphetamine saccharate and d,l-amphetamine aspartate monohydrate. The Adderall XR capsule contains two types of drug-containing beads designed to give a double-pulsed delivery of amphetamines, which prolongs the release of amphetamine from Adderall XR compared to the conventional Adderall (immediate-release) tablet formulation.

Each capsule contains: 5 mg 10 mg 15 mg 20 mg 25 mg 30 mg
Dextroamphetamine Saccharate 1.25 mg 2.50mg 3.75 mg 5.1 mg 6.25 mg 7.5 mg
Amphetamine Aspartate Monohydrate 1.25 mg 2.5mg 3.75 mg 5.0 mg 6.25 mg 7.5 mg
Dextroamphetamine Sulfate USP 1.26 mg 2.50mg 3.76 mg 5.1 mg 6.24 mg 7.50 mg
Amphetamine Sulfate USP 1.25 mg 2.5mg 3.76 mg 5.1 mg 6.24 mg 7.50 mg
Total amphetamine base equivalence 3.2 mg 6.2mg 9.5 mg 12.5mg 15.7 mg 18.7 mg

Uses of Adderall XR

Adderall XR is approved by FDA to treat ADHD and narcolepsy.

Off-Label Uses of Adderall XR

Adderall XR can be used as an adjunct for treatment-resistant depression.

Before Taking Adderall XR:

A diagnosis of ADHD can only be made if a person experiences symptoms of dysfunction / impulsivity or apathy before the age of 7 years.

There is no single test to diagnose ADHD. Diagnosis requires the use of medical, psychological, educational and social resources. Diagnosis is made based on the patient’s history and examination.

Patients taking divided doses of Adderall’s immediate dosage (such as twice a day) can be switched to Adderall XR at the same daily dose taken once a day.

Adderall XR is titrated on a weekly basis to ensure good endurance.

In Short
Adderall XR should be used as part of a comprehensive treatment program for ADHD. Other treatments may include psychological, educational, and social support.

Precautions and Contraindications for Taking Adderall XR

The stimulants are not intended to be used in patients who show symptoms due to natural conditions or those with other mental illnesses, such as psychosis.

Psychological and educational interventions often help, and medications should only be used when such interventions fail to resolve symptoms. A physician’s willingness to consider rehabilitation measures depends on the severity of the symptoms when remedies alone are not sufficient.

Stimulant drugs cause a small increase in blood pressure (approximately 2 to 4 mmHg) and a slight increase in heart rate (about 3 to 6 beats per minute). Some people may find a significant increase. These changes would not be expected to lead to short-term outcomes, but all patients should be considered for significant changes in blood pressure and heart rate.

Caution should be exercised in patients whose condition may be affected by an increase in heart rate and blood pressure, as follows:

  • high blood pressure

  • heart failure

  • recent myocardial infarction

  • ventricular arrhythmia.

Prior to starting Adderall XR, people undergoing treatment should have a careful history (including family history of sudden death or ventricular arrhythmia) and physical examination to check for cardiovascular disease and should receive further cardiac tests if there is evidence of disease. Patients who experience symptoms such as chest tightness, unexplained weakness, or other symptoms that may indicate heart problems should be evaluated immediately for heart failure.

Incentives can increase symptoms in anyone with an existing psychiatric disorder.

Treatment-induced psychiatric symptoms or symptoms in children or adolescents without a previous history of mania or psychosis can be caused by stimulant, or by usual doses. Symptoms may include insanity, deception, or episodes of manic. In the event of symptoms, discontinuation of treatment may be appropriate. In a short-term, placebo-controlled study, such symptoms occurred in approximately 0.1% of patients treated with stimulants.

Aggressive behavior is a common symptom seen in children with ADHD. While there is no evidence that stimulant cause behavior or hostility, patients starting treatment for ADHD should be monitored for increased violence or hostility.

Special care should be taken in using stimulants to treat ADHD patients with comorbid bipolar disorder due to concerns that the drug may cause mixed / manic episodes. Before starting any stimulant, patients should be evaluated for the risk of bipolar disorder.

Dosage for Adderall XR

Adderall XR is administered with a very low operating volume. Dosages depend on the patient’s treatment needs and response.

All dosage listed refer to the manufacturer. Check your prescription, and talk to your doctor to make sure you are taking the right dose.

  • For children between the ages of 6 and 12, the medication usually starts at 10mg once a day in the morning. The dose can be adjusted with an increase of 5mg or 10mg at certain times of the week. There may be times when the doctor decides to start the dose at 5mg once in the morning. The highest recommended dose for children ages 6 to 12 is 30mg / day. Doses larger than 30mg / day have not been studied in children. Adderall XR has not been studied in children under 6 years of age.

  • For children with ADHD between the ages of 13 and 17, the recommended first dose is 10mg / day. The dose can be increased to 20mg / day after one week if the symptoms of ADHD are not adequately controlled.

  • For adults, the recommended dose is 20mg per day.

Adderall XR comes with capsules. It should be taken by mouth. Capsules should be swallowed whole. They should not be chewed or crushed, as this can remove all the drugs at once and increase the risk of side effects.

Adderall XR capsule)

Side Effects of Adderall XR

It is important to talk to your doctor about what to expect in terms of side effects.

Common effects

  • Headache
  • Decreased appetite
  • Nervousness
  • Mood swings
  • Dizziness
  • Stomach ache
  • Trouble sleeping
  • Weight loss
  • Dry mouth
  • Fast heartbeat

Severe effects

  • Seizures
  • Slowing of growth or height in children
  • Eyesight changes or blurred vision

Tell your doctor if you have any side effects that bother you or are chronic. This is not all the possible side effects of Adderall XR. For more information, consult your doctor or pharmacist. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Experience of Clinical Studies

The pre-marketing development program for Adderall XR included exposure to 1315 participants in clinical trials (635 pediatric patients, 350 young patients, 248 adult patients, and 82 healthy adult studies). Of these, 635 patients (ages 6 to 12) were evaluated in two controlled clinical studies, one open-label study, and two single-dose clinical studies (N = 40). Negative reactions were assessed by collecting adverse reactions, physical examination results, vital signs, instruments, laboratory analysis, and ECGs.

Adverse reactions during exposure were mainly detected by routine investigations and recorded by clinical investigators using terms of their choice. As a result, it is not possible to provide a balanced estimate of the number of people experiencing adverse reactions without first distinguishing the same types of responses from a small number of common event categories.

Adverse Reactions Leading to Discontinuation of Treatment

In two placebo-controlled studies of up to 5 weeks among children with ADHD, 2.4% (10/425) of patients with Adderall XR discontinued due to adverse reactions (including 3 malnourished patients, one of whom reported insomnia) compared with 2.7% (7/259) receiving placebo.

The most common reaction leading to Adderall XR discontinuation in controlled and uncontrolled clinical trials, of high doses of children (N = 595) were;

  • anorexia (loss of appetite) (2.9%)

  • insomnia (1.5%)

  • weight loss (1.2%)

  • emotional functioning 1%)

  • depression (0.7%)

More than half of these patients have been exposed to Adderall XR for 12 months or more.

In a separate 4-placebo-controlled study in children with ADHD, five patients (2.1%) stopped treatment due to adverse events among patients with Adderall XR (N = 233) compared with one who received placebo (N = 54). The worst event that led to discontinuation was considered drug-related (meaning leading to withdrawal of at least 1% of patients with Adderall XR and at least twice the placebo rate) was insomnia (1.3%, n = 3). In one 4-week placebo-controlled study among adults with ADHD doses of 20 mg to 60 mg, 23 patients (12.0%) stopped treatment due to adverse events among patients with Adderall XR (N = 191) compared with one patient (1.6%) who received a placebo (N = 64). The most serious adverse events that led to withdrawal and were considered drug-related (meaning leading to withdrawal of at least 1% of patients with ADDERALL XR and at least twice the placebo rate) were;

  • insomnia (5.2%, n = 10)

  • anxiety (2.1%, n = 4)

  • depression (1.6%, n = 3)

  • dry mouth (1.6%, n = 3)

  • anorexia (1.6%, n = 3)

  • tachycardia (1.6%, n = 3)

  • headache (1.6 %, n = 3)

  • asthenia (1.0%, n = 2)

Frequently Asked Questions

Following are the frequently asked questions related to this topic

1. Can Adderall XR be taken twice a day?

Both Adderall and Adderall XR can be taken with or without food. Adderall: Initial doses will vary, but doctors usually start adults and children at 5 mg once or twice a day. Adderall XR: Initial doses will vary, but doctors usually start adults at 20 mg once a day, and children at 10 mg once a day.

2. How long does it take for Adderall XR to kick in 20mg?

Adderall and Adderall XR (amphetamine and dextroamphetamine): Adderall starts working in about 30 minutes to one hour. Adderall’s effects start to wear out after four hours. The Adderall XR lasts about 12 hours.

3. How do I know if Adderall is working?

It is unlikely that Adderall will make all the symptoms of ADHD go away, but you will know that it works when other symptoms develop like the ability to stay focused on the task and complete it. Adderall may work if someone with ADHD says they are doing better at work or school.


Adderall XR is a prescription drug used to treat the symptoms of narcolepsy and deficit hyperactivity disorder (ADHD). Adderall XR can be used alone or with other medications. Adderall XR belongs to a class of drugs called stimulants. It is not known whether Adderall XR is safe and effective for children under three years of age. You may also take 2 Adderall XR at the same time if you have told your doctor about it and your doctor recommended you according to your situation.

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