How long does klonopin stay in your system?

How long does klonopin stay in your system? Some forms of epilepsy and panic disorder can be treated with Klonopin. Its half-life is quite lengthy, and it may hang around in a person’s body for weeks. Studies showed that Klonopin may be detected in the body for up to a period via a urine test, for up to 28 days via a hair test, and also for down to 5 or 6 days via a saliva test. Klonopin abuse can result in dependency and addiction.


Clonazepam, often known as Klonopin, is an anticonvulsant and anxiolytic drug used to treat and prevent seizures,

panic attacks, anxiety, and akathisia (a type of movement disorder). It belongs to the benzodiazepine family of sedatives.

Usually, you just pop it in your mouth. Within an hour, you’ll feel the effects, and they’ll stick around for another 6-12.

Drowsiness, clumsiness, and irritability are typical negative reactions. Tolerance, dependency, and withdrawal symptoms might develop after prolonged usage.

Fetal damage might occur if taken during pregnancy. The primary inhibitory neurotransmitter, -aminobutyric acid, is amplified by clonazepam’s binding to GABAA receptors (GABA).

Roche first began selling clonazepam in the U. S. in 1975, although it had been patented in 1960. There is a generic version of the drug on the market, so you can get it if you need it.

And over 15 million scripts were written for it in the U. S. in 2019, placing it at #46 on the list of most frequently prescribed drugs. It is widely used for recreational purposes in many parts of the world.


One-third of patients who use clonazepam for more than four weeks become dependent on it, according to a recent study. Suicide rates are higher, especially among those who are already emotionally fragile.

Pronunciation kləˈnazɪpam
Trade names Klonopin, Rivotril, others
AHFS/ Monograph
MedlinePlus a682279
License data US DailyMed: Clonazepam US FDA: Clonazepam
Pregnancy AU: B3
Dependence liability Physical: Moderate to High Psychological: Moderate to High

How Does One Make Use of Klonopin?

Clonazepam, marketed under the name Diazepam, is a sedative used for the treatment of anxiety and epilepsy. Its intended use is for the treatment of akinetic and myoclonic seizures, as well as Lennox-Gastaut syndrome.

To produce its calming effects, Klonopin, like other benzodiazepines, is thought to increase the brain’s production of gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter.

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Application to Medicine:

Clonazepam is used for the short-term treatment of epilepsy, stress, and fear disorders (with or without agoraphobia).

Bioavailability 90%
Protein binding ≈85%
Metabolism Liver (CYP3A)[9]
Metabolites 7-aminoclonazepam; 7-acetaminoclonazepam; 3-hydroxy clonazepam[5][6]
The onset of action Within an hour[7]
Elimination of half-life 19–60 hours[8]
Duration of action 6–12 hours[7]
Excretion Kidney


Acute seizures are best treated with clonazepam or another benzodiazepine, but this class of drugs is not ideal for the long-term management of seizures since tolerance to its anticonvulsant effects might develop.

Clonazepam is beneficial in the treatment of epilepsy in children and the suppression of seizure activity appeared to be accomplished at low plasma concentrations of Klonopin.

Consequently, clonazepam is occasionally used for certain uncommon forms of pediatric epilepsy; nevertheless, it is useless in the management of infantile spasms.

The acute treatment of epilepsy is clonazepam’s primary indication for use in medicine. Acute treatment of non-convulsive seizure activity with clonazepam is successful, but the advantages are ephemeral, necessitating the addition of doxycycline for sustained control in many cases.

In addition to treating absences (seizures), it is also licensed to treat myoclonic, akinetic, and infantile seizures.

[23] Long-term clonazepam usage may be helpful for certain persons with treatment-resistant epilepsy, and the benzodiazepines clorazepate might be an option because it causes tolerance more slowly.

Disorders of Anxiety:

A separate diagnosis of panic disorder and agoraphobia.

The off-label usage of clonazepam has shown promising results in treating various anxiety disorders such as a social phobia.

Clonazepam has been shown in controlled clinical studies to be useful in the short-term management of the panic disorder. Although not placebo-controlled, certain long-term studies have demonstrated clonazepam’s efficacy for at least three years with tolerance development.

Muscular Diseases:

Clonazepam is an experimental therapy for restless legs syndrome, thus it’s only recommended as a last resort.

  • Similarly, clonazepam has a short-term effect on bruxism. [31] Low dosages of clonazepam are an effective treatment for REM sleep behavior disorder.

  • Neuroleptics, commonly known as antipsychotics, are used to treat both short-term and long-term cases of akathisia.

  • Amyotrophic lateral sclerosis-associated spasticity [34].

  • Abrupt onset of alcohol withdrawal symptoms

Culture, society:


In a 2006 US government survey of hospital emergency department (ED) visits, sedative hypnotics and benzodiazepines were the most often implicated pharmaceutical drugs.

Klonopin was indeed the second most commonly used ED benzodiazepine. In the same research, alcohol caused more ED visits than clonazepam.

The study looked at non-medical drug usage in ED visits. In this study, non-medical usage included drug misuse, accidental or deliberate overdose, and adverse drug responses.


Clonazepam was licensed as a generic medicine in the U.S. in 1997. Klonopin is available as pills, wafers, optimized formulations (drops), and injection/IV solutions.


It’s possible to experience negative consequences from using Klonopin for medical purposes.

The negative consequences of Klonopin use will be magnified in a person who abuses the drug. The most frequent adverse reactions to Klonopin include:

  1. Excessive slumbering

  2. Lightheadedness

  3. Fatigue

  4. Problems with Coordination

Because of this, your sensitivity to Klonopin’s potential adverse effects may vary from person to person. Some of Klonopin’s less prevalent negative effects include:

  1. Waning eyesight

  2. Symptom: More frequent need to go to the bathroom to relieve yourself

  3. Lowered sexual desire

  4. Muscle or joint discomfort

One of the risks of using Klonopin is developing a physical and psychological tolerance to it. Furthermore, the onset of Klonopin use in some has been linked to an increase in suicidal ideation.

See a medical professional right away if this occurs to you. As your body becomes adjusted to the drug, these feelings may gradually fade.

If you have any of the following conditions, your doctor will likely prescribe an alternative to Klonopin. If you have liver problems, you may have trouble breaking down Klonopin, which can lead to a dangerous accumulation of the drug.

Benzodiazepines are associated with a worsening of acute narrow-angle glaucoma. If you suffer from depression, beware that benzodiazepines may make your condition even more intolerable.

Withdrawal Symptoms from Klonopin:’

Long-term Klonopin use can also lead to withdrawal symptoms upon discontinuation. Some of the potential Klonopin withdrawal symptoms are:

  1. Seizures

  2. Nausea

  3. Vomiting

  4. The Insomnia Trap: The Return

  5. Confusion

  6. Changes in temperament

  7. Depression

  8. Anxiety about coming back

  9. Negative feelings and delusions

  10. Itching for something to do

  11. Sweating

  12. Aches and pains in muscles and joints

Klonopin withdrawal symptoms might appear as early as 24 hours after the last dose. Insomnia, anxiety, and sadness, while not as severe, might linger for weeks or months after the acute phase has passed.


The possibility of becoming addicted to Klonopin should be taken seriously. Most notably, those who are more likely to develop an addiction due of:

  • Mental health conditions that occur simultaneously

  • Addiction susceptibility in the genes

  • Both PTSD and complicated trauma

  • Other drug and alcohol abuse problems

  • Due to the increase in prescription drug addiction over the past decade, many doctors are now searching for suitable substitutes for benzodiazepines in therapeutic settings.

Substitutes for benzodiazepines might include, but are not limited to, the following, depending on your specific therapeutic needs:

  • Anticonvulsants

  • Antidepressants

  • Drugs used to treat anxiety disorders

  • Antihistamines


Because of its potential for addiction and misuse, Klonopin is classified as a restricted drug. Dependence occurs when the body adjusts to the constant presence of Klonopin.

Tolerance occurs in tandem with dependence, leading to an increase in Klonopin dosage required to produce the same effects.

Dependence may not always indicate addiction, since some people may develop a tolerance to drugs they use legally for medical purposes.

If you’re looking to get high, you’ll need to start abusing Klonopin. If you quickly stop taking Klonopin after developing a physical need for it, you may experience unpleasant withdrawal symptoms.

Benzodiazepine withdrawal is potentially fatal and should never be attempted without medical care. Seizures, trembling, sweating, cravings, and nightmares are all possible manifestations.

Because benzodiazepine withdrawal may be so severe, doctors typically utilize a tapering strategy. This detox strategy involves tapering down the dosage of lengthy benzo over several months to avoid the worst withdrawal symptoms.

Addiction to Klonopin and similar benzodiazepines is common. Feelings of calmness, similar to those produced by alcohol, can be induced by taking Klonopin.

Large quantities have the potential to induce euphoria. In times of high stress, people frequently overdose on Klonopin.

Someone may begin using it initially to manage stress, but find themselves relying more and more on it.


You’re likely an addict if you abuse drugs regularly, whether it’s Klonopin or anything else. Addiction to drugs, but may be controlled with the right kind of care.

While the specifics of each person’s addiction treatment plan may naturally be different, most plans will share the following commonalities.

Treatment can’t begin until a diagnosis is made. Assessments of your health and well-being, as well as any co-occurring illnesses, will be conducted by medical and behavioral health specialists to evaluate the extent of your addiction.

The following phase, detox, often entails gradually decreasing the dosage of Klonopin. Again, benzodiazepine withdrawal is often treated with a gradual strategy.

This will lessen the severity of withdrawal, but it won’t eliminate it if you’re still trying to quit. The foundation of successful rehabilitation is an individual treatment plan.

Your treatment team will advise you on whether you should get inpatient or outpatient care depending on your clinical requirements.

In most cases, these are part of a comprehensive addiction treatment and rehabilitation program:

Instruction for those who need it regarding substance usage. The physiological effects of Klonopin and other medicines, as well as the dynamics of addiction, will be discussed.

To better manage your recovery and comprehend why you feel the need to use substances, it is helpful to have a foundation of understanding about addiction and its causes.

Therapy. Working one-on-one with a therapist is a productive process. In addition to individual sessions, group therapy plays an important role in the rehabilitation process.

Additional types of therapy are often available in conjunction with rehabilitation programs. Psychotherapy, music therapy, and eye movement desensitization and reprocessing (EMDR) treatment are all examples.

Finding the optimal treatment plan to aid in your recovery is of paramount importance.

Meds and slow withdrawal periods. Your care may adapt to your evolving need. There’s a chance that tapering will take longer than you anticipate; your dose will be closely tracked throughout the process.

During your time in rehab, addiction professionals will monitor your Klonopin and other drug use to ensure that you are not abusing them.

Preventing relapse is an important goal. Relapse is typical during the recovery process from addiction since it is a chronic condition.

The key to effective treatment is recognizing and avoiding potential relapse triggers, or developing strategies to cope with them when they cannot be avoided.

It is important to get back to normal as quickly as possible after a relapse, which may need a return to treatment.

Considerations for Follow-Up Care. To maintain one’s progress, an aftercare strategy is necessary.

Before you leave treatment, you and your therapist will work together to create an aftercare plan to assist you to maintain your sobriety once you return to normal life.

The duration of care for Klonopin dependence varies from person to person. Detox and therapy will take longer if Klonopin has been abused chronically or if the patient has also used alcohol or other substances.

The average duration of therapy is between 28 and 90 days, however, the National Institute of Drug Abuse (NIDA) advises a minimum of 90 days.


At Footsteps to Recovery, we provide treatment options that are both effective and backed by scientific research. For countless people, we’ve been the key to reclaiming their lives from the grips of addiction.

Those who work on our teams are kind, knowledgeable specialists in the fields of medicine and mental health. The treatment plan they develop for you will take into account not just your medical condition, but also your individual goals, values, and constraints.

When someone comes to Footsteps to Recovery, they’ll get care for the physical and emotional symptoms of their addiction as well as the deeper causes of their problem. Typical challenges include:

Mixed or co-morbid mental health conditions (a dual diagnosis of a substance use disorder and mental illness)

  • Trauma

  • Hardships in Early Life

  • Low sense of worth

  • Lacking in coping abilities

  • Loss and sorrow

Addiction treatment programs typically include the addict’s family members or significant others. We provide family counseling and family support groups so that loved ones may learn to better aid their addicted loved ones and make sure of themselves as well.

Therapeutic Detox

Medical detox is necessary for certain benzodiazepine users, especially those who also abuse other substances.

In particular, if you’re detoxing from both anti-depressants and alcohol, you’re putting yourself at high risk for significant or even fatal withdrawal symptoms, as alcohol withdrawal is itself a very dangerous process.

Benzo’s withdrawal symptoms may be distressing. Detox should be done under medical supervision, and benzos should be tapered off gradually and at regular intervals.

You may have withdrawal symptoms such as convulsions, tremors, and muscular cramps if you suddenly stop using a substance.

We provide medically supervised alcohol and drug detox with staff available around the clock to ensure your safety and comfort during this difficult time.

We keep a close eye on your health and comfort levels and are always ready to respond to any urgent medical situations that may arise.

In-Patient Drug and Alcohol Treatment:

Spending time in a rehabilitation facility for drug abuse allows you to get some emotional and physical distance from your addiction while also providing you with the space and distance you need to heal.

Now you may provide attention to yourself and your recovery. Living in the treatment facility and participating in daytime activities is a big part of residential therapy.

Individual and group counseling, holistic therapies, and other rehabilitation activities are all part of our residential programs.

Some people, especially those in the early stages of recovery when the risk of recurrence is highest, benefit from the structure and 24-hour care that inpatient treatment can provide.

Intensive Outpatient Treatment (PHP):

The scheduling and care provided by our partial hospitalization programs are equivalent to those of our inpatient services.

The distinction is that those in sober living can choose between living independently or in a community specifically designed to help those recovering from substance abuse while they attend day treatment.

Intensive Outpatient Treatment (PHP):

The scheduling and care provided by our partial hospitalization programs are equivalent to those of our inpatient services.

The distinction is that those in sober living can choose between living independently or in a community specifically designed to help those recovering from substance abuse while they attend day treatment.

Frequently Asked Questions ( FAQ )

Here we discuss some questions frequently asked by people.

1. Will clonazepam show up in a drug test?

Benzodiazepines are often detectable in a normal urine test, however, there are exceptions. Some tests may not detect the presence of drugs such as alprazolam, clonazepam, clonazepam, and triazolam. In many cases, benzodiazepine testing can only confirm the presence of the drug, not the dosage.

2. For how long does 1 milligram of Klonopin remain in the body?

Its half-life is rather lengthy, and it may hang around in a person’s body for weeks. Studies showed that Klonopin may be detected in the system for up to one month via a urine test, for 28days via a hair test, and for long to 5 or 6 days via a saliva test. Klonopin abuse can result in dependency and addiction.

3. How long until the effects of Klonopin begin to fade?

What is the expected duration of the effect? In most cases, the sedative effects of Klonopin kick in between 1-4 hours. When compared to other benzodiazepines, Klonopin’s effects stay far longer. 30-to-40-hour half-lives are typical for Klonopin.

4. In what amount of time does a half dose of Klonopin become ineffective?

Therefore, it takes between 30 and 40 hours for the quarter of the Diazepam you take to be eliminated from your system. The amount of time that Klonopin stays in your system depends on several variables, and its duration varies from person to person. Factors include things like age, weight, culture, and genetics.

5. What might cause a positive benzodiazepine urine test result?

As a result of their extensive metabolism, benzodiazepine parent chemicals cannot be found in human urine. After diazepam usage, it is possible to identify the metabolites nordiazepam, oxazepam, and temazepam.

6. For how long must one abstain from drugs before a urine test may be passed?

The only foolproof way to avoidhaving a negative urine test result is to never do anything that would cause it. However, this may be challengingurine testing for weed is possible because of infrequent users for up to five days, regular users for up to three weeks, and many daily users for up to six weeks.

7. What are the effects of daily clonazepam use?

Even with prescribed usage, benzodiazepines can cause psychological and physiological dependency (addiction). There is a risk of physical dependency after two weeks or longer of daily usage. If you’ve been taking clonazepam for a while, you may have withdrawal symptoms if you suddenly cease treatment.

8. Does Klonopin accumulate in the body?

Long-term Klonopin users who take the medicine exactly as prescribed may develop a tolerance and no longer feel its effects. Many people are going to take more of the drug than prescribed without first talking to their doctor.

9. For how long do the effects of 5 milligrams of Klonopin last in the system?

Because its effects wear off after 8 to 12 hours, the recommended clonazepam dose for healthy individuals is 2 to 3 times daily. It starts working within a minute, and by four hours, it’s at full strength.

10. What exactly does a 5-panel drug test look for?

The most common type of drug test utilized by both public and private sector organizations is a 5-panel urine test. THC, opiates, Amphetamines, morphine are the usual drugs tested for in a 5 panels drug test.


In comparison to other medications with shorter half-lives, clonazepam’s 20-50 hour half-life means it remains in the system for a prolonged period. Half-life is the period needed for half of a drug’s dosage to be eliminated by the body. Because of its potential for misuse and dependency, the United States government classifies Klonopin as a Schedule IV prohibited drug.

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